The 34th Conference on Intelligent Systems for Molecular Biology (ISMB) is the flagship meeting of the International Society for Computational Biology (ISCB). This year's conference takes place July 12–14 in Washington, returning to the city to celebrate 30 years of advancing computational biology. We're also delighted to be sponsoring the 27th annual Bioinformatics Open Source Conference (BOSC), taking place July 14–15 as part of ISMB 2026.